Upregulation of pro-inflammatory genes accompanies photoreceptors demise in canine models of retinal degeneration
نویسندگان
چکیده
These abstracts are licensed under a Creative Commons Attribution-NonCommercial-No Derivatives 4.0 International License. Go to http://iovs.arvojournals.org/ to access the versions of record. 378 Cellular mechanisms of retinal diseases and ocular therapeutics Tuesday, May 09, 2017 3:45 PM–5:30 PM Exhibit/Poster Hall Poster Session Program #/Board # Range: 3587–3601/B0146–B0160 Organizing Section: Biochemistry/Molecular Biology
منابع مشابه
Strong upregulation of inflammatory genes accompanies photoreceptor demise in canine models of retinal degeneration
We have analyzed the complex pattern of the inflammatory response in early-onset canine models of human retinitis pigmentosa, rcd1, xlpra2 and erd, as well as late-onset xlpra1, in comparative manner. The time course of immune response genes and proteins expression was examined along the timeline of photoreceptors degeneration. Gene expression analysis of the early-onset models prior to and aft...
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We used quantitative real-time PCR to examine the expression of 112 genes related to retinal function and/or belonging to known pro-apoptotic, cell survival, and autophagy pathways during photoreceptor degeneration in three early-onset canine models of human photoreceptor degeneration, rod cone dysplasia 1 (rcd1), X-linked progressive retinal atrophy 2 (xlpra2), and early retinal degeneration (...
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تاریخ انتشار 2017